Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response

PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is a predominantly fatal common malignancy with inadequate treatment options. Glycogen synthase kinase 3β (GSK-3β) is an emerging target in human malignancies including PDAC. EXPERIMENTAL DESIGN: Pancreatic cancer cell lines and patient-derived xenogr...

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Udgivet i:Clin Cancer Res
Main Authors: Ding, Li, Madamsetty, Vijay S., Kiers, Spencer, Alekhina, Olga, Ugolkov, Andrey, Dube, John, Zhang, Yu, Zhang, Jin-San, Wang, Enfeng, Dutta, Shamit K., Schmitt, Daniel M., Giles, Francis J., Kozikowski, Alan P., Mazar, Andrew P., Mukhopadhyay, Debabrata, Billadeau, Daniel D.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825568/
https://ncbi.nlm.nih.gov/pubmed/31533931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0799
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