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TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
The ATR (ATM and Rad3-related) kinase and its regulatory partner ATRIP (ATR-interacting protein) coordinate checkpoint responses to DNA damage and replication stress. TopBP1 functions as a general activator of ATR. However, the mechanism by which TopBP1 activates ATR is unknown. Here, we show that A...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2418584/ https://ncbi.nlm.nih.gov/pubmed/18519640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1666208 |
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