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Function of the ATR N-terminal domain revealed by an ATM/ATR chimera
The ATM and ATR kinases function at the apex of checkpoint signaling pathways. These kinases share significant sequence similarity, phosphorylate many of the same substrates, and have overlapping roles in initiating cell cycle checkpoints. However, they sense DNA damage through distinct mechanisms....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1855264/ https://ncbi.nlm.nih.gov/pubmed/17376433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2007.02.015 |
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