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Sensitive Oligodeoxynucleotide Synthesis Using Dim and Dmoc as Protecting Groups
In traditional oligodeoxynucleotide (ODN) synthesis, phosphate groups are protected with 2-cyanoethyl group, and amino groups are protected with acyl groups. At the end of ODN synthesis, deprotection is achieved with strong bases and nucleophiles. Therefore, traditional technologies are not suitable...
Gardado en:
| Publicado en: | J Org Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6825528/ https://ncbi.nlm.nih.gov/pubmed/31536351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b01527 |
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