Electrophilic oligodeoxynucleotide synthesis using dM-Dmoc for amino protection

Solid-phase synthesis of electrophilic oligodeoxynucleotides (ODNs) was achieved using dimethyl-Dmoc (dM-Dmoc) as amino protecting group. Due to the high steric hindrance of the 2-(propan-2-ylidene)-1,3-dithiane side product from deprotection, the use of excess nucleophilic scavengers such as anilin...

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Bibliographic Details
Published in:Beilstein J Org Chem
Main Authors: Shahsavari, Shahien, Eriyagama, Dhananjani N A M, Halami, Bhaskar, Begoyan, Vagarshak, Tanasova, Marina, Chen, Jinsen, Fang, Shiyue
Format: Artigo
Language:Inglês
Published: Beilstein-Institut 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6541367/
https://ncbi.nlm.nih.gov/pubmed/31164948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.15.108
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