Therapeutic role of a cysteine precursor, OTC, in ischemic stroke is mediated by improved proteostasis in mice

Oxidative stress aggravates brain injury following ischemia/reperfusion (I/R). We previously showed that ubiquilin-1 (Ubqln1), a ubiquitin-like protein, improves proteostasis and protects brains against oxidative stress and I/R induced brain injury. Here, we demonstrate that a small molecule compoun...

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Bibliografiske detaljer
Udgivet i:Transl Stroke Res
Main Authors: Liu, Yanying, Min, Jia-Wei, Feng, Shelley, Subedi, Kalpana, Qiao, Fangfang, Mammenga, Emily, Callegari, Eduardo, Wang, Hongmin
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824933/
https://ncbi.nlm.nih.gov/pubmed/31049841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12975-019-00707-w
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