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The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier

TRAAK is a membrane tension-activated K(+) channel that has been associated through behavioral studies to mechanical nociception. We used specific monoclonal antibodies in mice to show that TRAAK is localized exclusively to nodes of Ranvier, the action potential propagating elements of myelinated ne...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Brohawn, Stephen G, Wang, Weiwei, Handler, Annie, Campbell, Ernest B, Schwarz, Jürgen R, MacKinnon, Roderick
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824864/
https://ncbi.nlm.nih.gov/pubmed/31674909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50403
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