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Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K(+) channel

TRAAK (TWIK-related arachidonic acid-stimulated K(+) channel, K2P4.1) K(+) ion channels are expressed predominantly in the nervous system to control cellular resting membrane potential and are regulated by mechanical and chemical properties of the lipid membrane. TRAAK channels are twofold symmetric...

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Detalhes bibliográficos
Main Authors: Brohawn, Stephen G., Campbell, Ernest B., MacKinnon, Roderick
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568379/
https://ncbi.nlm.nih.gov/pubmed/23341632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218950110
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