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The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier

TRAAK is a membrane tension-activated K(+) channel that has been associated through behavioral studies to mechanical nociception. We used specific monoclonal antibodies in mice to show that TRAAK is localized exclusively to nodes of Ranvier, the action potential propagating elements of myelinated ne...

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Publicat a:eLife
Autors principals: Brohawn, Stephen G, Wang, Weiwei, Handler, Annie, Campbell, Ernest B, Schwarz, Jürgen R, MacKinnon, Roderick
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824864/
https://ncbi.nlm.nih.gov/pubmed/31674909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50403
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