Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors

A limiting factor for the use of adeno-associated viruses (AAVs) as vectors in gene therapy is the broad tropism of AAV serotypes, i.e., the parallel infection of several cell types. Nanobodies are single immunoglobulin variable domains from heavy chain antibodies that naturally occur in camelids. T...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Eichhoff, Anna Marei, Börner, Kathleen, Albrecht, Birte, Schäfer, Waldemar, Baum, Natalie, Haag, Friedrich, Körbelin, Jakob, Trepel, Martin, Braren, Ingke, Grimm, Dirk, Adriouch, Sahil, Koch-Nolte, Friedrich
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819893/
https://ncbi.nlm.nih.gov/pubmed/31687421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.09.003
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