Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors

A limiting factor for the use of adeno-associated viruses (AAVs) as vectors in gene therapy is the broad tropism of AAV serotypes, i.e., the parallel infection of several cell types. Nanobodies are single immunoglobulin variable domains from heavy chain antibodies that naturally occur in camelids. T...

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Библиографические подробности
Опубликовано в: :Mol Ther Methods Clin Dev
Главные авторы: Eichhoff, Anna Marei, Börner, Kathleen, Albrecht, Birte, Schäfer, Waldemar, Baum, Natalie, Haag, Friedrich, Körbelin, Jakob, Trepel, Martin, Braren, Ingke, Grimm, Dirk, Adriouch, Sahil, Koch-Nolte, Friedrich
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Gene & Cell Therapy 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819893/
https://ncbi.nlm.nih.gov/pubmed/31687421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.09.003
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