A cDNA Immunization Strategy to Generate Nanobodies against Membrane Proteins in Native Conformation

Nanobodies (Nbs) are soluble, versatile, single-domain binding modules derived from the VHH variable domain of heavy-chain antibodies naturally occurring in camelids. Nbs hold huge promise as novel therapeutic biologics. Membrane proteins are among the most interesting targets for therapeutic Nbs be...

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Bibliografiska uppgifter
I publikationen:Front Immunol
Huvudupphovsmän: Eden, Thomas, Menzel, Stephan, Wesolowski, Janusz, Bergmann, Philine, Nissen, Marion, Dubberke, Gudrun, Seyfried, Fabienne, Albrecht, Birte, Haag, Friedrich, Koch-Nolte, Friedrich
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2018
Ämnen:
Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787055/
https://ncbi.nlm.nih.gov/pubmed/29410663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01989
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