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Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity

Adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NAD(+)) are released as danger signals from cells during infection and sterile inflammation. In the extracellular compartment ATP is converted by CD39, CD73, and other ecto-enzymes into metabolites that modulate the activity of T ce...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Menzel, Stephan, Schwarz, Nicole, Haag, Friedrich, Koch-Nolte, Friedrich
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880931/
https://ncbi.nlm.nih.gov/pubmed/29636685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00266
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