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Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics

Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal target recognition module of a conventional antibody is composed of two non-covalently associated variable domains (VH an...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Bannas, Peter, Hambach, Julia, Koch-Nolte, Friedrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702627/
https://ncbi.nlm.nih.gov/pubmed/29213270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01603
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