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Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics

Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal target recognition module of a conventional antibody is composed of two non-covalently associated variable domains (VH an...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Bannas, Peter, Hambach, Julia, Koch-Nolte, Friedrich
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702627/
https://ncbi.nlm.nih.gov/pubmed/29213270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01603
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