CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells

CD38 is overexpressed by multiple myeloma cells and has emerged as a target for therapeutic antibodies. Nanobodies are soluble single domain antibody fragments derived from the VHH variable domain of heavy chain antibodies naturally occurring in camelids. We previously identified distinct llama nano...

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Vydáno v:Front Immunol
Hlavní autoři: Schütze, Kerstin, Petry, Katharina, Hambach, Julia, Schuster, Niklas, Fumey, William, Schriewer, Levin, Röckendorf, Jana, Menzel, Stephan, Albrecht, Birte, Haag, Friedrich, Stortelers, Catelijne, Bannas, Peter, Koch-Nolte, Friedrich
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262402/
https://ncbi.nlm.nih.gov/pubmed/30524421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02553
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