CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells

CD38 is overexpressed by multiple myeloma cells and has emerged as a target for therapeutic antibodies. Nanobodies are soluble single domain antibody fragments derived from the VHH variable domain of heavy chain antibodies naturally occurring in camelids. We previously identified distinct llama nano...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Schütze, Kerstin, Petry, Katharina, Hambach, Julia, Schuster, Niklas, Fumey, William, Schriewer, Levin, Röckendorf, Jana, Menzel, Stephan, Albrecht, Birte, Haag, Friedrich, Stortelers, Catelijne, Bannas, Peter, Koch-Nolte, Friedrich
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262402/
https://ncbi.nlm.nih.gov/pubmed/30524421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02553
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