Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38(+) tumors in mouse models in vivo

The cell surface ecto-enzyme CD38 is a promising target antigen for the treatment of hematological malignancies, as illustrated by the recent approval of daratumumab for the treatment of multiple myeloma. Our aim was to evaluate the potential of CD38-specific nanobodies as novel diagnostics for hema...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Fumey, William, Koenigsdorf, Julia, Kunick, Valentin, Menzel, Stephan, Schütze, Kerstin, Unger, Mandy, Schriewer, Levin, Haag, Friedrich, Adam, Gerhard, Oberle, Anna, Binder, Mascha, Fliegert, Ralf, Guse, Andreas, Zhao, Yong Juan, Cheung Lee, Hon, Malavasi, Fabio, Goldbaum, Fernando, van Hegelsom, Rob, Stortelers, Catelijne, Bannas, Peter, Koch-Nolte, Friedrich
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662768/
https://ncbi.nlm.nih.gov/pubmed/29084989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14112-6
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