Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38(+) tumors in mouse models in vivo

The cell surface ecto-enzyme CD38 is a promising target antigen for the treatment of hematological malignancies, as illustrated by the recent approval of daratumumab for the treatment of multiple myeloma. Our aim was to evaluate the potential of CD38-specific nanobodies as novel diagnostics for hema...

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Publicado en:Sci Rep
Main Authors: Fumey, William, Koenigsdorf, Julia, Kunick, Valentin, Menzel, Stephan, Schütze, Kerstin, Unger, Mandy, Schriewer, Levin, Haag, Friedrich, Adam, Gerhard, Oberle, Anna, Binder, Mascha, Fliegert, Ralf, Guse, Andreas, Zhao, Yong Juan, Cheung Lee, Hon, Malavasi, Fabio, Goldbaum, Fernando, van Hegelsom, Rob, Stortelers, Catelijne, Bannas, Peter, Koch-Nolte, Friedrich
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662768/
https://ncbi.nlm.nih.gov/pubmed/29084989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14112-6
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