Targeting CD38-Expressing Multiple Myeloma and Burkitt Lymphoma Cells In Vitro with Nanobody-Based Chimeric Antigen Receptors (Nb-CARs)

The NAD-hydrolyzing ecto-enzyme CD38 is overexpressed by multiple myeloma and other hematological malignancies. We recently generated CD38-specific nanobodies, single immunoglobulin variable domains derived from heavy-chain antibodies naturally occurring in llamas. Nanobodies exhibit high solubility...

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Pubblicato in:Cells
Autori principali: Hambach, Julia, Riecken, Kristoffer, Cichutek, Sophia, Schütze, Kerstin, Albrecht, Birte, Petry, Katharina, Röckendorf, Jana Larissa, Baum, Natalie, Kröger, Nicolaus, Hansen, Timon, Schuch, Gunter, Haag, Friedrich, Adam, Gerhard, Fehse, Boris, Bannas, Peter, Koch-Nolte, Friedrich
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072387/
https://ncbi.nlm.nih.gov/pubmed/32013131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9020321
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