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Positive Cooperativity in Substrate Binding by Human Thymidylate Synthase
Thymidylate synthase (TS) catalyzes the production of the nucleotide dTMP from deoxyuridine monophosphate (dUMP), making the enzyme necessary for DNA replication and consequently a target for cancer therapeutics. TSs are homodimers with active sites separated by ∼30 Å. Reports of half-the-sites acti...
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| Pubblicato in: | Biophys J |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Biophysical Society
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6818155/ https://ncbi.nlm.nih.gov/pubmed/31500803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.08.015 |
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