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Bacterial Thymidylate Synthase Binds Two Molecules of Substrate and Cofactor without Cooperativity
Thymidylate synthase (TSase) is a clinically important enzyme because it catalyzes synthesis of the sole de novo source of deoxy-thymidylate. Without this enzyme, cells die a “thymineless death” since they are starved of a crucial DNA synthesis precursor. As a drug target, TSase is well studied in t...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4699426/ https://ncbi.nlm.nih.gov/pubmed/26517288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b10128 |
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