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Inter-Active Site Communication Mediated by the Dimer Interface Beta-Sheet in the Half-the-Sites Enzyme, Thymidylate Synthase.
Thymidylate synthase (TS) is a dimeric enzyme conserved in all life forms that exhibits the allosteric feature of half-the-sites activity. Neither the reason for, nor the mechanism of this phenomenon is understood. We used a combined NMR and molecular dynamics approach to study a stable intermediate...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7110413/ https://ncbi.nlm.nih.gov/pubmed/31283187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00486 |
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