Folic Acid–Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting

[Image: see text] Drug–target interaction, cellular internalization, and target engagement should be addressed to design a lead with high chances of success in further optimization stages. Accordingly, we have designed conjugates of folic acid with anticancer peptides able to bind human thymidylate...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Med Chem
Prif Awduron: Marverti, Gaetano, Marraccini, Chiara, Martello, Andrea, D’Arca, Domenico, Pacifico, Salvatore, Guerrini, Remo, Spyrakis, Francesca, Gozzi, Gaia, Lauriola, Angela, Santucci, Matteo, Cannazza, Giuseppe, Tagliazucchi, Lorenzo, Cazzato, Addolorata Stefania, Losi, Lorena, Ferrari, Stefania, Ponterini, Glauco, Costi, Maria P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2021
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041318/
https://ncbi.nlm.nih.gov/pubmed/33710891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c02107
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