Folic Acid–Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting

[Image: see text] Drug–target interaction, cellular internalization, and target engagement should be addressed to design a lead with high chances of success in further optimization stages. Accordingly, we have designed conjugates of folic acid with anticancer peptides able to bind human thymidylate...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Marverti, Gaetano, Marraccini, Chiara, Martello, Andrea, D’Arca, Domenico, Pacifico, Salvatore, Guerrini, Remo, Spyrakis, Francesca, Gozzi, Gaia, Lauriola, Angela, Santucci, Matteo, Cannazza, Giuseppe, Tagliazucchi, Lorenzo, Cazzato, Addolorata Stefania, Losi, Lorena, Ferrari, Stefania, Ponterini, Glauco, Costi, Maria P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041318/
https://ncbi.nlm.nih.gov/pubmed/33710891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c02107
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