Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations

SIMPLE SUMMARY: Drug combinations may help overcome drug resistance, a relevant cause of failure of ovarian cancer therapy. However, designing successful combinations requires a lengthy preclinical validation process. We have analyzed combinations of 5-fluorouracil and raltitrexed, two anticancer dr...

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Publicado en:Cancers (Basel)
Main Authors: Pozzi, Cecilia, Santucci, Matteo, Marverti, Gaetano, D’Arca, Domenico, Tagliazucchi, Lorenzo, Ferrari, Stefania, Gozzi, Gaia, Losi, Lorena, Tassone, Giusy, Mangani, Stefano, Ponterini, Glauco, Costi, Maria Paola
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8123127/
https://ncbi.nlm.nih.gov/pubmed/33923290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13092061
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