Načítá se...

Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology

Demonstrating a candidate drug’s interaction with its target protein in live cells is of pivotal relevance to the successful outcome of the drug discovery process. Although thymidylate synthase (hTS) is an important anticancer target protein, the efficacy of the few anti-hTS drugs currently used in...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Ponterini, Glauco, Martello, Andrea, Pavesi, Giorgia, Lauriola, Angela, Luciani, Rosaria, Santucci, Matteo, Pelà, Michela, Gozzi, Gaia, Pacifico, Salvatore, Guerrini, Remo, Marverti, Gaetano, Costi, Maria Paola, D’Arca, Domenico
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890114/
https://ncbi.nlm.nih.gov/pubmed/27250901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27198
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!