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Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology

Demonstrating a candidate drug’s interaction with its target protein in live cells is of pivotal relevance to the successful outcome of the drug discovery process. Although thymidylate synthase (hTS) is an important anticancer target protein, the efficacy of the few anti-hTS drugs currently used in...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Ponterini, Glauco, Martello, Andrea, Pavesi, Giorgia, Lauriola, Angela, Luciani, Rosaria, Santucci, Matteo, Pelà, Michela, Gozzi, Gaia, Pacifico, Salvatore, Guerrini, Remo, Marverti, Gaetano, Costi, Maria Paola, D’Arca, Domenico
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890114/
https://ncbi.nlm.nih.gov/pubmed/27250901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27198
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