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Backbone and ILVM methyl resonance assignments of human thymidylate synthase in apo and substrate bound forms

Human thymidylate synthase (hTS) is a 72 kDa homodimeric enzyme responsible for the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), making it the sole source of de novo dTMP in human cells. As a result, hTS is an attractive anti-cancer therapeutic target. Addi...

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Bibliographic Details
Published in:Biomol NMR Assign
Main Authors: Bonin, Jeffrey P., Lee, Andrew L.
Format: Artigo
Language:Inglês
Published: 2021
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979492/
https://ncbi.nlm.nih.gov/pubmed/33486616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12104-021-10006-x
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