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Backbone and ILVM methyl resonance assignments of human thymidylate synthase in apo and substrate bound forms
Human thymidylate synthase (hTS) is a 72 kDa homodimeric enzyme responsible for the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), making it the sole source of de novo dTMP in human cells. As a result, hTS is an attractive anti-cancer therapeutic target. Addi...
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| Veröffentlicht in: | Biomol NMR Assign |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7979492/ https://ncbi.nlm.nih.gov/pubmed/33486616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12104-021-10006-x |
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