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Backbone-independent NMR resonance assignments of methyl probes in large proteins

Methyl-specific isotope labeling is a powerful tool to study the structure, dynamics and interactions of large proteins and protein complexes by solution-state NMR. However, widespread applications of this methodology have been limited by challenges in obtaining confident resonance assignments. Here...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Nerli, Santrupti, De Paula, Viviane S., McShan, Andrew C., Sgourakis, Nikolaos G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846771/
https://ncbi.nlm.nih.gov/pubmed/33514730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-20984-0
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