Cilastatin protects against imipenem-induced nephrotoxicity via inhibition of renal organic anion transporters (OATs)

Imipenem is a carbapenem antibiotic. However, Imipenem could not be marketed owing to its instability and nephrotoxicity until cilastatin, an inhibitor of renal dehydropeptidase-I (DHP-I), was developed. In present study, the potential roles of renal organic anion transporters (OATs) in alleviating...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Huo, Xiaokui, Meng, Qiang, Wang, Changyuan, Zhu, Yanna, Liu, Zhihao, Ma, Xiaodong, Ma, Xiaochi, Peng, Jinyong, Sun, Huijun, Liu, Kexin
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804466/
https://ncbi.nlm.nih.gov/pubmed/31649848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.02.005
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