Organic anion transporters also mediate the drug–drug interaction between imipenem and cilastatin

This study aimed to clarify that organic anion transporters (OATs) mediate the drug–drug interaction (DDI) between imipenem and cilastatin. After co-administration with imipenem, the plasma concentrations and the plasma concentration-time curve (AUC) of cilastatin were significantly increased, while...

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Detalhes bibliográficos
Publicado no:Asian J Pharm Sci
Main Authors: Zhu, Yanna, Huo, Xiaokui, Wang, Changyuan, Meng, Qiang, Liu, Zhihao, Sun, Huijun, Tan, Aiping, Ma, Xiaodong, Peng, Jinyong, Liu, Kexin
Formato: Artigo
Idioma:Inglês
Publicado em: Shenyang Pharmaceutical University 2020
Assuntos:
Research article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7193450/
https://ncbi.nlm.nih.gov/pubmed/32373203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajps.2018.11.006
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