Organic anion transporters also mediate the drug–drug interaction between imipenem and cilastatin

This study aimed to clarify that organic anion transporters (OATs) mediate the drug–drug interaction (DDI) between imipenem and cilastatin. After co-administration with imipenem, the plasma concentrations and the plasma concentration-time curve (AUC) of cilastatin were significantly increased, while...

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Bibliographic Details
Published in:Asian J Pharm Sci
Main Authors: Zhu, Yanna, Huo, Xiaokui, Wang, Changyuan, Meng, Qiang, Liu, Zhihao, Sun, Huijun, Tan, Aiping, Ma, Xiaodong, Peng, Jinyong, Liu, Kexin
Format: Artigo
Language:Inglês
Published: Shenyang Pharmaceutical University 2020
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Research article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7193450/
https://ncbi.nlm.nih.gov/pubmed/32373203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajps.2018.11.006
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