Protective effect of cilastatin against diclofenac‐induced nephrotoxicity through interaction with diclofenac acyl glucuronide via organic anion transporters

BACKGROUND AND PURPOSE: Diclofenac is a widely used nonsteroidal anti‐inflammatory drug. However, adverse effects in the kidney limit its clinical application. The present study was aimed to evaluate the potential effect of cilastatin on diclofenac‐induced acute kidney injury and to clarify the pote...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Huo, Xiaokui, Meng, Qiang, Wang, Changyuan, Wu, Jingjing, Wang, Chong, Zhu, Yanna, Ma, Xiaodong, Sun, Huijun, Liu, Kexin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7161545/
https://ncbi.nlm.nih.gov/pubmed/32000294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14957
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