Protective effect of cilastatin against diclofenac‐induced nephrotoxicity through interaction with diclofenac acyl glucuronide via organic anion transporters

BACKGROUND AND PURPOSE: Diclofenac is a widely used nonsteroidal anti‐inflammatory drug. However, adverse effects in the kidney limit its clinical application. The present study was aimed to evaluate the potential effect of cilastatin on diclofenac‐induced acute kidney injury and to clarify the pote...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Huo, Xiaokui, Meng, Qiang, Wang, Changyuan, Wu, Jingjing, Wang, Chong, Zhu, Yanna, Ma, Xiaodong, Sun, Huijun, Liu, Kexin
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7161545/
https://ncbi.nlm.nih.gov/pubmed/32000294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14957
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