Cilastatin protects against imipenem-induced nephrotoxicity via inhibition of renal organic anion transporters (OATs)

Imipenem is a carbapenem antibiotic. However, Imipenem could not be marketed owing to its instability and nephrotoxicity until cilastatin, an inhibitor of renal dehydropeptidase-I (DHP-I), was developed. In present study, the potential roles of renal organic anion transporters (OATs) in alleviating...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Acta Pharm Sin B
Prif Awduron: Huo, Xiaokui, Meng, Qiang, Wang, Changyuan, Zhu, Yanna, Liu, Zhihao, Ma, Xiaodong, Ma, Xiaochi, Peng, Jinyong, Sun, Huijun, Liu, Kexin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2019
Pynciau:
Original article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804466/
https://ncbi.nlm.nih.gov/pubmed/31649848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.02.005
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