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Polyphosphates diminish solubility of a globular protein and thereby promote amyloid aggregation
Structural changes of globular proteins and their resultant amyloid aggregation have been associated with various human diseases, such as lysozyme amyloidosis and light-chain amyloidosis. Because many globular proteins can convert into amyloid fibrils in vitro, the mechanisms of amyloid fibril forma...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6802520/ https://ncbi.nlm.nih.gov/pubmed/31439662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008662 |
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