Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress

Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer-related deaths globally. Despite advances in diagnosis and treatment, the incidence and mortality of HCC continue to rise. Piperlongumine (PL), an alkaloid isolated from the fruit of the long pepper,...

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Foilsithe in:Front Pharmacol
Main Authors: Zhang, Qianqian, Chen, Weiqian, Lv, Xiuling, Weng, Qiaoyou, Chen, Minjiang, Cui, Ri, Liang, Guang, Ji, Jiansong
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2019
Ábhair:
Pharmacology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802400/
https://ncbi.nlm.nih.gov/pubmed/31680962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01180
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