Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation

The thioredoxin reductase (TrxR) 1 is often overexpressed in numerous cancer cells. Targeting TrxR1 leads to a reduction in tumor progression and metastasis, making the enzyme an attractive target for cancer treatment. Our previous research revealed that the curcumin derivative B19 could induce canc...

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Pubblicato in:Oncotarget
Autori principali: Chen, Weiqian, Zou, Peng, Zhao, Zhongwei, Weng, Qiaoyou, Chen, Xi, Ying, Shilong, Ye, Qingqing, Wang, Zhe, Ji, Jiansong, Liang, Guang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941337/
https://ncbi.nlm.nih.gov/pubmed/26919094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7565
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