Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer

Gastric cancer (GC) is one of the leading causes of cancer mortality in the world. In addressing the need of treatments for relapsed disease, we report the identification of an existing U.S. Food and Drug Administration-approved small-molecule drug to repurpose for GC treatment. Auranofin (AF), clin...

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Vydáno v:Oncotarget
Hlavní autoři: Zou, Peng, Chen, Minxiao, Ji, Jiansong, Chen, Weiqian, Chen, Xi, Ying, Shilong, Zhang, Junru, Zhang, Ziheng, Liu, Zhiguo, Yang, Shulin, Liang, Guang
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742192/
https://ncbi.nlm.nih.gov/pubmed/26431378
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