Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer

Gastric cancer (GC) is one of the leading causes of cancer mortality in the world. In addressing the need of treatments for relapsed disease, we report the identification of an existing U.S. Food and Drug Administration-approved small-molecule drug to repurpose for GC treatment. Auranofin (AF), clin...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Zou, Peng, Chen, Minxiao, Ji, Jiansong, Chen, Weiqian, Chen, Xi, Ying, Shilong, Zhang, Junru, Zhang, Ziheng, Liu, Zhiguo, Yang, Shulin, Liang, Guang
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742192/
https://ncbi.nlm.nih.gov/pubmed/26431378
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