TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy

Thioredoxin reductase-1 (TrxR1)-, glutathione reductase (Gsr)-, and Nrf2 transcription factor-driven antioxidant systems form an integrated network that combats potentially carcinogenic oxidative damage yet also protects cancer cells from oxidative death. Here we show that although unchallenged wild...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: McLoughlin, Michael R., Orlicky, David J., Prigge, Justin R., Krishna, Pushya, Talago, Emily A., Cavigli, Ian R., Eriksson, Sofi, Miller, Colin G., Kundert, Jean A., Sayin, Volkan I., Sabol, Rachel A., Heinemann, Joshua, Brandenberger, Luke O., Iverson, Sonya V., Bothner, Brian, Papagiannakopoulos, Thales, Shearn, Colin T., Arnér, Elias S. J., Schmidt, Edward E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561278/
https://ncbi.nlm.nih.gov/pubmed/31097586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903244116
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