TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy

Thioredoxin reductase-1 (TrxR1)-, glutathione reductase (Gsr)-, and Nrf2 transcription factor-driven antioxidant systems form an integrated network that combats potentially carcinogenic oxidative damage yet also protects cancer cells from oxidative death. Here we show that although unchallenged wild...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: McLoughlin, Michael R., Orlicky, David J., Prigge, Justin R., Krishna, Pushya, Talago, Emily A., Cavigli, Ian R., Eriksson, Sofi, Miller, Colin G., Kundert, Jean A., Sayin, Volkan I., Sabol, Rachel A., Heinemann, Joshua, Brandenberger, Luke O., Iverson, Sonya V., Bothner, Brian, Papagiannakopoulos, Thales, Shearn, Colin T., Arnér, Elias S. J., Schmidt, Edward E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561278/
https://ncbi.nlm.nih.gov/pubmed/31097586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903244116
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