Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death

Because of its key role in cancer development and progression, STAT3 has become an attractive target for developing new cancer therapeutics. While several STAT3 inhibitors have progressed to advanced stages of development, their underlying biology and mechanisms of action are often more complex than...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Adv
Auteurs principaux: Busker, S., Qian, W., Haraldsson, M., Espinosa, B., Johansson, L., Attarha, S., Kolosenko, I., Liu, J., Dagnell, M., Grandér, D., Arnér, E. S. J., Tamm, K. Pokrovskaja, Page, B. D. G.
Format: Artigo
Langue:Inglês
Publié: American Association for the Advancement of Science 2020
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083616/
https://ncbi.nlm.nih.gov/pubmed/32219156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax7945
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