Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death

Because of its key role in cancer development and progression, STAT3 has become an attractive target for developing new cancer therapeutics. While several STAT3 inhibitors have progressed to advanced stages of development, their underlying biology and mechanisms of action are often more complex than...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Busker, S., Qian, W., Haraldsson, M., Espinosa, B., Johansson, L., Attarha, S., Kolosenko, I., Liu, J., Dagnell, M., Grandér, D., Arnér, E. S. J., Tamm, K. Pokrovskaja, Page, B. D. G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083616/
https://ncbi.nlm.nih.gov/pubmed/32219156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax7945
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