Alantolactone promotes ER stress‐mediated apoptosis by inhibition of TrxR1 in triple‐negative breast cancer cell lines and in a mouse model

Triple‐negative breast cancer (TNBC) is a subtype of breast cancer with poor clinical outcome and currently no effective targeted therapies are available. Alantolactone (ATL), a sesquiterpene lactone, has been shown to have potential anti‐tumour activity against various cancer cells. However, the un...

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Veröffentlicht in:J Cell Mol Med
Hauptverfasser: Yin, Changtian, Dai, Xuanxuan, Huang, Xiangjie, Zhu, Wangyu, Chen, Xi, Zhou, Qiulin, Wang, Canwei, Zhao, Chengguang, Zou, Peng, Liang, Guang, Rajamanickam, Vinothkumar, Wang, Ouchen, Zhang, Xiaohua, Cui, Ri
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378194/
https://ncbi.nlm.nih.gov/pubmed/30609207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14139
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