Phenotype onset in Huntington’s disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene

Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock‐in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into the mouse Htt gene, whereas in the Q1...

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Veröffentlicht in:J Neurosci Res
Hauptverfasser: Franich, Nicholas R., Hickey, Miriam A., Zhu, Chunni, Osborne, Georgina F., Ali, Nadira, Chu, Tiffany, Bove, Nicholas H., Lemesre, Vincent, Lerner, Renata P., Zeitlin, Scott O., Howland, David, Neueder, Andreas, Landles, Christian, Bates, Gillian P., Chesselet, Marie‐Francoise
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Huntington's Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6801054/
https://ncbi.nlm.nih.gov/pubmed/31282030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.24493
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