Phenotype onset in Huntington’s disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene

Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock‐in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into the mouse Htt gene, whereas in the Q1...

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Dettagli Bibliografici
Pubblicato in:J Neurosci Res
Autori principali: Franich, Nicholas R., Hickey, Miriam A., Zhu, Chunni, Osborne, Georgina F., Ali, Nadira, Chu, Tiffany, Bove, Nicholas H., Lemesre, Vincent, Lerner, Renata P., Zeitlin, Scott O., Howland, David, Neueder, Andreas, Landles, Christian, Bates, Gillian P., Chesselet, Marie‐Francoise
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Huntington's Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6801054/
https://ncbi.nlm.nih.gov/pubmed/31282030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.24493
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