Early Motor Dysfunction and Striosomal Distribution of Huntingtin Microaggregates in Huntington's Disease Knock-In Mice

Huntington's disease (HD) is characterized by a progressive loss of neurons in the striatum and cerebral cortex and is caused by a CAG repeat expansion in the gene encoding huntingtin. Mice with the mutation inserted into their own huntingtin gene (knock-in mice) are, genetically, the best mode...

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Publicado no:J Neurosci
Main Authors: Menalled, Liliana B., Sison, Jessica D., Wu, Ying, Olivieri, Melisa, Li, Xiao-Jiang, Li, He, Zeitlin, Scott, Chesselet, Marie-Françoise
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2002
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758087/
https://ncbi.nlm.nih.gov/pubmed/12223581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-18-08266.2002
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