Phenotype onset in Huntington’s disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene

Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock‐in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into the mouse Htt gene, whereas in the Q1...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Neurosci Res
Egile Nagusiak: Franich, Nicholas R., Hickey, Miriam A., Zhu, Chunni, Osborne, Georgina F., Ali, Nadira, Chu, Tiffany, Bove, Nicholas H., Lemesre, Vincent, Lerner, Renata P., Zeitlin, Scott O., Howland, David, Neueder, Andreas, Landles, Christian, Bates, Gillian P., Chesselet, Marie‐Francoise
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2019
Gaiak:
Huntington's Disease
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6801054/
https://ncbi.nlm.nih.gov/pubmed/31282030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.24493
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak