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Ctf4 organizes sister replisomes and Pol α into a replication factory
The current view is that eukaryotic replisomes are independent. Here we show that Ctf4 tightly dimerizes CMG helicase, with an extensive interface involving Psf2, Cdc45, and Sld5. Interestingly, Ctf4 binds only one Pol α-primase. Thus, Ctf4 may have evolved as a trimer to organize two helicases and...
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| Izdano u: | eLife |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
eLife Sciences Publications, Ltd
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6800005/ https://ncbi.nlm.nih.gov/pubmed/31589141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47405 |
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