Ctf4 organizes sister replisomes and Pol α into a replication factory

The current view is that eukaryotic replisomes are independent. Here we show that Ctf4 tightly dimerizes CMG helicase, with an extensive interface involving Psf2, Cdc45, and Sld5. Interestingly, Ctf4 binds only one Pol α-primase. Thus, Ctf4 may have evolved as a trimer to organize two helicases and...

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Veröffentlicht in:eLife
Hauptverfasser: Yuan, Zuanning, Georgescu, Roxana, Santos, Ruda de Luna Almeida, Zhang, Daniel, Bai, Lin, Yao, Nina Y, Zhao, Gongpu, O'Donnell, Michael E, Li, Huilin
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2019
Schlagworte:
Biochemistry and Chemical Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800005/
https://ncbi.nlm.nih.gov/pubmed/31589141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47405
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