Ctf4 organizes sister replisomes and Pol α into a replication factory

The current view is that eukaryotic replisomes are independent. Here we show that Ctf4 tightly dimerizes CMG helicase, with an extensive interface involving Psf2, Cdc45, and Sld5. Interestingly, Ctf4 binds only one Pol α-primase. Thus, Ctf4 may have evolved as a trimer to organize two helicases and...

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Sparad:
Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Yuan, Zuanning, Georgescu, Roxana, Santos, Ruda de Luna Almeida, Zhang, Daniel, Bai, Lin, Yao, Nina Y, Zhao, Gongpu, O'Donnell, Michael E, Li, Huilin
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2019
Ämnen:
Biochemistry and Chemical Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800005/
https://ncbi.nlm.nih.gov/pubmed/31589141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47405
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