Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation

Alanine-serine-cysteine transporter 2 (ASCT2, SLC1A5) is the primary transporter of glutamine in cancer cells and regulates the mTORC1 signaling pathway. The SLC1A5 function involves finely tuned orchestration of two domain movements that include the substrate-binding transport domain and the scaffo...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Yu, Xiaodi, Plotnikova, Olga, Bonin, Paul D, Subashi, Timothy A, McLellan, Thomas J, Dumlao, Darren, Che, Ye, Dong, Yin Yao, Carpenter, Elisabeth P, West, Graham M, Qiu, Xiayang, Culp, Jeffrey S, Han, Seungil
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800002/
https://ncbi.nlm.nih.gov/pubmed/31580259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48120
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