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Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5

Cancer cells undergo a shift in metabolism where they become reliant on nutrients such as the amino-acid glutamine. Glutamine enters the cell via the alanine/serine/cysteine transporter 2 (ASCT2) that is upregulated in several cancers to maintain an increased supply of this nutrient and are therefor...

詳細記述

保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Scopelliti, Amanda J, Font, Josep, Vandenberg, Robert J, Boudker, Olga, Ryan, Renae M
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750217/
https://ncbi.nlm.nih.gov/pubmed/29295993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02444-w
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