The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)

The transporters for glutamine and essential amino acids, ASCT2 (solute carrier family 1 member 5, SLC1A5) and LAT1 (solute carrier family 7 member 5, SLC7A5), respectively, are overexpressed in aggressive cancers and have been identified as cancer-promoting targets. Moreover, previous work has sugg...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Cormerais, Yann, Massard, Pierre André, Vucetic, Milica, Giuliano, Sandy, Tambutté, Eric, Durivault, Jerome, Vial, Valérie, Endou, Hitoshi, Wempe, Michael F., Parks, Scott K., Pouyssegur, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827425/
https://ncbi.nlm.nih.gov/pubmed/29326164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001342
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