ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

Alanine, serine, cysteine-preferring transporter 2 (ASCT2; SLC1A5) mediates uptake of glutamine, a conditionally essential amino acid in rapidly proliferating tumour cells. Uptake of glutamine and subsequent glutaminolysis is critical for activation of the mTORC1 nutrient-sensing pathway, which regu...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: van Geldermalsen, M, Wang, Q, Nagarajah, R, Marshall, A D, Thoeng, A, Gao, D, Ritchie, W, Feng, Y, Bailey, C G, Deng, N, Harvey, K, Beith, J M, Selinger, C I, O'Toole, S A, Rasko, J E J, Holst, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914826/
https://ncbi.nlm.nih.gov/pubmed/26455325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.381
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